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Motor proteins in megakaryocyte biology
Non-muscle myosin II (NMII) is the crucial motor proteins that drive mitotic division and regulate the transition from mitosis to endomitosis in megakaryocytes. This process is a crucial determinant of the size of the megakaryocytes and consequently the number of platelets that are extruded by each megakaryocyte. We study the regulation of NMII motor proteins in the context of platelet and RBC biology. READ MORE
Thrombopoietin receptor dynamics in health and disease
Mutant calreticulin driven myeloproliferative neoplasm
B cell acute lymphoblastic leukemia and IKAROS
Zebrafish model of thrombopoiesis
Zebrafish is a versatile model to study thrombopoiesis and related disorders. We analyze the thrombopoietin receptor signalling in Zebrafish. We recently identified a zebrafish specific Mapk14a- TpoR interaction. Along with the classical Jak2 dependent signaling, Mapk14a has been found to regulate thrombopoiesis in fish. READ MORE
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